Buy this book on-line Muller, Douw Gerbrant : 'n Ondersoek na die wisselwerking van natriumdiklofenak en asetielsalisielsuur in die mens(Bloemfontein: unpublished dissertation, 1980)
A dissertation submitted to fulfill the requirements for a Masters degree in Medical Science in the Department of Pharmacology at the University of the Orange Free State, though Potchefstroom University is credited on the upper cover. 295 x 208 mm; cloth-backed printed wrappers; pp. (vii) + 75 (printed rectos); tables; graphs. Trace of fishmothing to cloth spine. Very good condition. Afrikaans text. This work considers the possibility of pharmacokinetic interaction between aspirin and diclofenac sodium in humans, in cases of combined intake. Possible mechanisms of such interaction are explored. It is found that aspirin causes a drop of around 75% in the Cmax and nearly 50% in the AUC of diclofenac in humans. To explain the results, two hypotheses are suggested, namely: a) that diclofenac is biotransformed pre-systemically and/or b) that diclofenac is biotransformed rapidly, to a great extent in the first pass effect, and that the presence of aspirin and/or salicylic acid can influence these processes as a catalyst. The bibliography is entirely a list of works in English. Click here for full details of this book, to ask a question or to buy it on-line. Bibliophile Bookbase probably offers multiple copies of Muller, Douw Gerbrant : 'n Ondersoek na die wisselwerking van natriumdiklofenak en asetielsalisielsuur in die mens. Click here to select from a complete list of available copies of this book. Bibliophile Bookbase lists over 5 million books, maps and prints including atlases, libri antichi, rare books, livres anciens and collectables. Bibliophile Bookbase for antiquarian books, maps and prints. |